Tropical Journal of Pharmaceutical Research
Official Journal of Pharmacotherpy Group
 
Home Pharmacotherapy Group African Journals Online
 

Formulation and in vitro Evaluation of Eudragit Microspheres of Stavudine

Sunit Kumar Sahoo1, Abdul Arif Mallick1, BB Barik1 and Prakash Ch Senapati2

1University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Orissa 751004, India, 2Torrent Pharmaceuticals, Baddi

 

Tropical Journal of Pharmaceutical Research 2005; 4(1): 369-375 

ISSN: 1596-5996

 

Abstract

Purpose: The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of a highly water-soluble drug, stavudine, using Copolymers synthesized from acrylic and methacrylic acid esters (Eudragit RS 100 and RL 100) as the retardant material. .

Methods: Microspheres were prepared by solvent evaporation method using an acetone / liquid paraffin system. Magnesium stearate was used as the droplet stabilizer and n-hexane was added to harden the microspheres. The prepared microspheres were characterized for their micromeritic properties and drug loading, as well by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry, x-ray powder diffractometry and scanning electron microscopy. The in vitro release studies were performed in pH 6.8, phosphate buffer.

Results: The prepared microspheres were white, free flowing and spherical in shape. The drug-loaded microspheres showed 67-91% of entrapment and release was extended upto 6 to 8 h. The infrared spectra and differential scanning calorimetry thermographs showed stable character of stavudine in the drug-loaded microspheres and revealed the absence of drug-polymer interactions. X-ray diffraction patterns showed that there was decrease in crystallinity of the drug. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature.

Conclusion: The best-fit release kinetics was achieved with Higuchi plot followed by zero order and First order. The release of stavudine was influenced by the drug to polymer ratio and particle size & was found to be diffusion controlled.

 Key wordsStavudine, Eudragit, microspheres, controlled release, polymethacrylate

To whom correspondence should be addressed: E-mail: bwn02003@yahoo.co.in  Tel: 91-674-2582806

 


 

Abstract

Full Text (PDF)

Table of Contents

 

 

 

Letters

Comments to Editor

e-mail Alert  

 

Sign Up

 
Copyright @2002-2006. TJPR Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Tel: +234 802 3360318 Fax: +234 52 602257 E-mail: okhamafe@uniben.edu erah@uniben.edu p_erah@yahoo.com
 
Last updated: May 30, 2006