|Tropical Journal of Pharmaceutical Research|
|Official Journal of Pharmacotherpy Group|
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of hyperlipidaemia, hypercholesterolaemia and hyperketonaemia by aqueous
extract of Dioscorea dumetorum tuber
Department of Biochemistry, Faculty of Science, University of Benin, P.M.B. 1154, Benin City, Nigeria
Tropical Journal of Pharmaceutical Research 2003; 2(1): 183-189
Dioscorea dumetorum (Pax) used in traditional medicine for the treatment of
diabetes mellitus possesses hypoglycaemic effect. The present study investigates
the effect of oral administration of the aqueous extract of the tuber on blood
lipid and ketone levels in alloxan–induced diabetic rats.
Wistar strain albino rats were made diabetic with the intraperitoneal
administration of alloxan monohydrate. Consequently, an aqueous extract of
Dioscorea dumetorum tuber was administered orally to the diabetic rats and their
plasma and urine glucose, triacylglycerol, cholesterol and β-hydroxybutyrate
concentrations were estimated using standard procedures. Results were compared
with untreated normal and diabetic control rats. Phytochemical
screening of the extract of the tuber was also carried out.
Treatment with the extract significantly (p<0.05) reduced elevated blood
levels of triacylglycerol, cholesterol and b–hydroxybutyrate
associated with alloxan-induced diabetes mellitus. The aqueous extract tested
positive for flavonoids, alkaloids, saponins and cardiac glycosides.
From this study, the tuber has proved not only to be an effective
hypoglycaemic agent, but also possesses significant (p<0.05) hypolipidaemic
and hypocholesterolaemic properties while also ameliorating ketosis.
Alloxan, β-hydroxybutyrate, diabetes, cholesterol, Dioscorea dumetorum,
should be addressed:
|@2002-3. TJPR Faculty of Pharmacy, University of Benin, Benin City, Nigeria|
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|Last updated: August 19, 2003|