|Tropical Journal of Pharmaceutical Research|
|Official Journal of Pharmacotherpy Group|
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property of kaolin in some drug formulations
Anthony O Onyekweli1F, Cyril O Usifoh2, Lucky O Okunrobo2 and Jessica D Zuofa1
1Department of Pharmaceutics and Pharmaceutical Technology, and 2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin-City, Nigeria
Tropical Journal of Pharmaceutical Research 2003; 2(1): 155-159
is a known adsorbent, has lubricant property in powders and is therefore
proposed as a lubricant in tablet formulations. This study was carried out to
evaluate whether kaolin can adsorb some active drugs when mixed with them in
tablet formulations even at very low concentrations.
Chloroquine and chlorpheniramine tablets were formulated with powder
mixtures containing various concentrations of kaolin. The effect of kaolin on
the physical properties of the tablets were examined and compared with those of
standard lubricants like magnesium stearate and talc. Chloroquine and
chlorpheniramine tablets and powders of amoxicillin/clavulanic acid oral powder
and ampicillin/cloxacillin injection were also mixed with and without various
concentrations of kaolin in water. Chemical assay of the drugs in the solutions
were determined over time.
Kaolin significantly reduced the amount of each of the drugs in the
solutions containing kaolin.
Kaolin reduces the amount of some drugs when incorporated in drug
formulations. Therefore, its inclusion in such drug formulations should not be
ampicillin/cloxacillin, amoxicillin/clavulanic acid, chloroquine,
chlorpheniramine, drug formulation, kaolin.
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|Last updated: August 19, 2003|