|Tropical Journal of Pharmaceutical Research|
|Official Journal of Pharmacotherpy Group|
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of drug release from ensembles of aspirin microcapsules of certain particle size
Florence E EichieF and Roland S Okor
Department of Pharmaceutics, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Tropical Journal of Pharmaceutical Research 2003; 2(1): 137-145
In order to determine the
drug release profile of an ensemble of aspirin crystals or microcapsules from
its particle distribution a mathematical model that considered the individual
release characteristics of the component single particles was developed.
The model assumed that under sink conditions the release from individual
(component) particles would be independent of each other and hence simply
The release parameters, mt
= the amount of drug released in time t, m¥
= the maximum release and t¥
= the time to attain it were determined for each single particle by simulation
using previously derived mathematical models.
To obtain the cumulative release curve for the ensemble the individual
releases were summed up at each time scale and for the various time intervals.
Values of m¥
for the ensemble were obtained from the simulated cumulative curves.
The release profiles of the ensembles were also determined experimentally
and their m¥
values deduced from the release curves.
The observed cumulative curves of the ensembles compared favourably with the
simulated data. The % difference in
the observed and the simulated m¥
values of the ensembles was within ±
20%, which indicated that the modelling was valid.
The study showed that the
release profile of an ensemble can be determined from its particle distribution
which has application in controlled release studies.
Key words: Aspirin microcapsules, drug release simulation, multiparticulate systems
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|Last updated: August 19, 2003|